Search for dissertations about: "neuroblastoma"

Showing result 11 - 15 of 226 swedish dissertations containing the word neuroblastoma.

  2. 11. Preclinical investigation of novel therapies against neuroblastoma

    Author : Karin Hansson; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

    Abstract : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. READ MORE

  4. 12. Hypoxia and differentiation in human neuroblastoma cells

    Author : Helén Nilsson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ; teratology; cytogenetik; Development biology; cytogenetics; Genetik; Genetics; Medicin människa och djur ; HIF; Medicine human and vertebrates ; MYCN; Hypoxia; differentiation; Neuroblastoma;

    Abstract : The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. READ MORE

  5. 13. Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma

    Author : Arash Hamidian; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2α; enChIP; ESRRA; mTORC2; IGF-II; Hypoxia; Cancer; PI3K; Transcription; Neuroblastoma;

    Abstract : Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of high-risk children. READ MORE

  6. 14. bHLH transcription factors in differentiating neuroblastoma cells

    Author : Anna Grynfeld; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. READ MORE

  7. 15. Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors

    Author : Ulrika Bäckman; Rolf Christofferson; Sven Påhlman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Angiogenesis; Neuroblastoma; MYCN; VEGF; SU11657; SU5416; TNP-470; zoledronic acid; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. READ MORE