Search for dissertations about: "neurodegeneration"

Showing result 1 - 5 of 193 swedish dissertations containing the word neurodegeneration.

  1. 1. Pericytes in Neurodegeneration

    Author : Thomas Padel; Translationell Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pericyte; Parkinson disease; Huntington Disease; PDGF-BB; RGS5;

    Abstract : .... READ MORE

  2. 2. Molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

    Author : Abiodun Ajayi; Anna-Lena Ström; Ana Cristina Rego; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; neurodegeneration; oxidative stress; NOX; metabolism; p53; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the SCA7 gene resulting in progressive ataxia and retinal dystrophy. SCA7 belongs to a group of neurodegenerative disorders called polyglutamine (polyQ) diseases, that share the common feature of glutamine tract expansions within otherwise unrelated proteins. READ MORE

  3. 3. Study of molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

    Author : Abiodun Ajayi; Anna-Lena Ström; Boris Zhivotosky; Bengt Mannervik; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; neurodegeneration; polyglutamine; oxidative stress; metabolism; NADPH oxidase; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the SCA7/ATXN7 gene resulting in progressive ataxia and retinal dystrophy. SCA7 belongs to a group of neurodegenerative disorders called polyglutamine (polyQ) diseases, that share the common feature of glutamine tract expansions within otherwise unrelated proteins. READ MORE

  4. 4. Mass spectrometric investigation of protein nitration in inflammation and neurodegeneration

    Author : Henrik Ryberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : mass spectrometry; oxidative stress; nitrotyrosine; neurodegeneration; peroxynitrite; protein modification;

    Abstract : The nitration of tyrosine seems to be very common in human diseases and at least forty different diseases have been reported to be associated with an increased nitration of proteins. The nitration of proteins results in a modification of tyrosine, 3-nitrotyrosine (3-NT), which is stable. READ MORE

  5. 5. Mitochondrial dysfunction in neurodegeneration

    Author : Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

    Abstract : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). READ MORE