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Showing result 1 - 5 of 226 swedish dissertations matching the above criteria.

2. 1. Prion-like Proteins in Neurodegeneration

   Author : Tomas Roos; Experimentell demensforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Alzheimers och Parkinsons sjukdom är de vanligaste och näst vanligaste neurodegenerativa sjukdomarna som globalt drabbar ca 30 respektive 6 miljoner människor. I och med vår åldrande befolkning kommer det antalet bara att öka. READ MORE

4. 2. Visualising neurodegeneration in the living brain : Preclinical evaluation of PET radioligands

   Author : Mengfei Xiong; Stina Syvänen; Sahar Roshanbin; Joakim Bergström; Per Borghammer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; Alzheimer s disease; Parkinson s disease; SV2A; neurodegeneration; immunotherapy; transgenic mice; Medicinsk vetenskap; Medical Science; Analytical Chemistry; Analytisk kemi; Pharmacology; Farmakologi; Molekylär medicin; Molecular Medicine;

   Abstract : With an ageing population, the number of people suffering from Alzheimer’s disease (AD) and Parkinson’s disease (PD) escalates yearly. Pathological hallmarks of AD and PD include aggregated proteins and synaptic dysfunction. READ MORE

5. 3. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7

   Author : Frida Niss; Anna-Lena Ström; Einar Hallberg; Georg Auberger; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; SCA7; Polyglutamine diseases; RNA binding proteins; Aggregation; Stress granules; Chromatin organization; Quantitative image analysis; Nuclear envelope; Nuclear pore complex; Nucleocytoplasmic transport; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. READ MORE

6. 4. Pericytes in Neurodegeneration

   Author : Thomas Padel; Translationell Neurologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pericyte; Parkinson disease; Huntington Disease; PDGF-BB; RGS5;

   Abstract : .... READ MORE

7. 5. Quantitative MRI Biomarkers of Neurodegeneration in Multiple Sclerosis

   Author : Michael Platten; Tobias Granberg; Chunliang Wang; Fredrik Piehl; Sara Shams; Mattias Vågberg; KTH; Karolinska Institutet; Karolinska Institutet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Machine learning; Multiple sclerosis; Corpus callosum; Neurodegeneration; Medical Technology; Medicinsk teknologi;

   Abstract : Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that targets myelin in the brain and spinal cord. The corpus callosum connects the cerebral hemispheres and is composed of heavily myelinated axons. READ MORE