Search for dissertations about: "neurodegeneration"

Showing result 6 - 10 of 226 swedish dissertations containing the word neurodegeneration.

  2. 6. Molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

    Author : Abiodun Ajayi; Anna-Lena Ström; Ana Cristina Rego; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurodegeneration; oxidative stress; NOX; metabolism; p53; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the SCA7 gene resulting in progressive ataxia and retinal dystrophy. SCA7 belongs to a group of neurodegenerative disorders called polyglutamine (polyQ) diseases, that share the common feature of glutamine tract expansions within otherwise unrelated proteins. READ MORE

  4. 7. Study of molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

    Author : Abiodun Ajayi; Anna-Lena Ström; Boris Zhivotosky; Bengt Mannervik; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurodegeneration; polyglutamine; oxidative stress; metabolism; NADPH oxidase; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the SCA7/ATXN7 gene resulting in progressive ataxia and retinal dystrophy. SCA7 belongs to a group of neurodegenerative disorders called polyglutamine (polyQ) diseases, that share the common feature of glutamine tract expansions within otherwise unrelated proteins. READ MORE

  5. 8. Mass spectrometric investigation of protein nitration in inflammation and neurodegeneration

    Author : Henrik Ryberg; Göteborgs universitet; []
    Keywords : mass spectrometry; oxidative stress; nitrotyrosine; neurodegeneration; peroxynitrite; protein modification;

    Abstract : The nitration of tyrosine seems to be very common in human diseases and at least forty different diseases have been reported to be associated with an increased nitration of proteins. The nitration of proteins results in a modification of tyrosine, 3-nitrotyrosine (3-NT), which is stable. READ MORE

  6. 9. Mitochondrial dysfunction in neurodegeneration

    Author : Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

    Abstract : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). READ MORE

  7. 10. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Author : Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. READ MORE