Search for dissertations about: "neurodegenerativa sjukdomar"

Showing result 1 - 5 of 28 swedish dissertations containing the words neurodegenerativa sjukdomar.

  2. 1. Analytical Approaches to Neurodegenerative Disease Protein Aggregation

    Author : Henning Wiberg; Åsa Emmer; Torbjörn Gräslund; Leopold Ilag; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurodegenerative diseases; protein misfolding; protein aggregation; gel electrophoresis; isoelectric focusing; immunodetection; ELISA; immunoprecipitation; mass spectrometry; nanoelectrospray; liquid chromatography; neurodegenerativa sjukdomar; felveckade proteiner; proteinaggregering; geleektrofores; isoelektrisk fokusering; immundetektion; ELISA; immunoprecipitering; masspektrometri; nanoelektrospray; vätskekromatografi; Analytical chemistry; Analytisk kemi;

    Abstract : .... READ MORE

  4. 2. Studies of in vivo prostate amyloidosis and autoimmune responses towards amyloid structures in neurodegeneration

    Author : Kiran Yanamandra; Ludmilla Morozova-Roche; Dina Raveh; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; amyloidosis; immune reactivity; S100A8 A9; insulin; α-synuclein; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Abstract : By using multidisciplinary analysis of CA inclusions in prostate glands of patients diagnosed with prostate cancer, we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer. We have demonstrated that material closely resembling CA can be produced from S100A8/A9 in vitro and shows the characters of amyloids. READ MORE

  5. 3. Multiplexed antibody-based protein profiling in the pursuit of CSF biomarkers for neurodegenerative diseases

    Author : Sofia Bergström; Peter Nilsson; Anna Månberg; Markus Otto; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Protein profiling; suspension bead array; cerebrospinal fluid; biomarker discovery; proteomics; Bioteknologi; Biotechnology;

    Abstract : There is a desire for a transition from generic treatments designed for the average patient, towards more individual-based precision medicine. An increased knowledge about disease pathophysiology on a molecular level would be beneficial for this transition. READ MORE

  6. 4. Development of new affinity proteins for neurodegenerative disorders

    Author : Linnea C. Hjelm; John Löfblom; Stefan Ståhl; Hanna Lindberg; Ylva Ivarsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; sequestrins; amyloid beta; alpha-synuclein; phage display; affibodies; blood–brain barrier; Transferrin receptor; receptor-mediated transcytosis; recombinant spider silk; Biotechnology; Bioteknologi;

    Abstract : Neurodegenerative disorders include a full spectrum of diagnoses, including dementias and other neuronal diseases, characterised by degradation of neurons in the brain occurring along with disease progression. Amongst the dementias, the most prevalent are Alzheimer’s (AD) and Parkinson’s disease (PD) that affect millions of people worldwide. READ MORE

  7. 5. Cathepsin D released from lysosomes mediates apoptosis

    Author : Katarina Kågedal; Marja Jäättelä; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Last year (2002), the Nobel Prize in Physiology or Medicine was awarded to three scientists who have conducted pioneer research on programmed cell death. In the human body, more than a thousand billion cells are created every day, and an equal number die, thus programmed cell death, or apoptosis, is an important mechanism for maintaining tissue homeostasis and protecting against disease. READ MORE