Search for dissertations about: "neurofilament proteins"

Showing result 1 - 5 of 13 swedish dissertations containing the words neurofilament proteins.

  1. 1. Tau and neurofilament proteins in Alzheimer’s disease and related cell models

    Author : Cecilia Björkdahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AD; tau; neurofilament proteins; kinases; zinc; Hsp27; alphaB-crystallin;

    Abstract : Background and aims: Among those afflicted with dementia more than half suffer from Alzheimer’s disease (AD). Pathological hallmarks of the disease include aggregates of Abeta, so called amyloid plaques, and neurofibrillary tangles (NFTs) made up of hyperphosphorylated cytoskeletal proteins. READ MORE

  2. 2. Impulse noise and brain injury. An experimental study in rats

    Author : Annette Säljö Moberg; Göteborgs universitet; []
    Keywords : apoptosis; astrocytes; brain injury; blast; c-Fos; c-Jun; c-Myc; impulse noise; ; neurons; neurofilament; NSE; rat and S-100;

    Abstract : Abstract. Pressure waves, experienced as impulse noise, affect many body organs, although most attention has been paid to the inner ear. Impulse noise is produced by e.g. READ MORE

  3. 3. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia

    Author : Gustaf Österlundh; Göteborgs universitet; []
    Keywords : childhood acute lymphoblastic leukemia; methotrexate; neurotoxicity; cerebral blood flow; single photon emission computed tomography; cerebrospinal fluid; neuron-specific enolase; glia fibrillary acidic protein; neurofilament; ascorbyl radical;

    Abstract : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. READ MORE

  4. 4. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Author : Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Keywords : Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Abstract : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. READ MORE

  5. 5. Dementia Proteomics

    Author : Julia Remnestål; Peter Nilsson; Anna Månberg; Pieter Jelle Visser; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Proteomics; Alzheimer s disease; Frontotemporal dementia; Antibody array; Suspension bead array; Cerebrospinal fluid; Protein profiling; Biomarker discovery; Bioteknologi; Biotechnology;

    Abstract : The term dementia encompass a number of conditions arising as a consequence of tissue degeneration in the brain. This degeneration is caused by molecular events occurring on a cellular level including inflammation, defective waste disposal and accumulation of insoluble proteins and peptides. READ MORE