Search for dissertations about: "neuropathic pain IN RATS"
Showing result 1 - 5 of 23 swedish dissertations containing the words neuropathic pain IN RATS.
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1. Tetrodotoxin-resistant sodium channels in neuropathic pain
Abstract : Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. READ MORE
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2. Genetic differences in neuropathy and opioid responses in rats
Abstract : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. READ MORE
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3. Nerve injury induced pain and spinal cord stimulation
Abstract : Chronic neuropathic pain caused by injury to or disease in the nervous system is relatively common and results in major suffering, poor quality of life and incapacity. Such pain is a therapeutic challenge because a considerable portion of the patients fails to benefit from pharmacotherapy. READ MORE
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4. Behavioural and neurochemical effects and changes in gene expression in inflammatory and neuropathic pain
Abstract : Chronic pain is a common clinical problem, which causes great suffering, and there is a great need for better analgesic drugs and strategies to counteract the transition of acute pain into chronic pain states. In studies of neurochemical mechanisms in animal models of chronic pain it is important to study also the development of spontaneous pain-related behaviour and sensory abnormalities (i. READ MORE
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5. The role of galanin in chronic pain mechanisms
Abstract : The general aim of these studies is to further elucidate the role of galanin in pain mechanisms. We have utilized normal and genetically modified animals and a variety of techniques. READ MORE