Search for dissertations about: "neuropilin-1"
Showing result 1 - 5 of 10 swedish dissertations containing the word neuropilin-1.
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1. Neuropilin-1 regulation of tumor vascularization and growth
Abstract : Angiogenesis, the formation of new blood vessels from existing ones, is dysregulated during tumor progression as a result of chronic hypoxia and inflammation. Such alterations lead to a lack of vessel hierarchy, and the formation of poorly perfused, leaky and blunt-ended vessels, contributing to disease progression. READ MORE
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2. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration
Abstract : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. READ MORE
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3. VEGFR-2 in Endothelial Differentiation and Vascular Organization
Abstract : The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. READ MORE
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4. Activity-regulated retinoic acid signaling in olfactory sensory neurons
Abstract : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. READ MORE
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5. Vascular metabolomics : gene regulation and role of VEGF-B in tissue fatty acid uptake
Abstract : Vascular endothelial growth factor B (VEGF‐B) belongs to the VEGF family, which constitutes of five mammalian members. VEGFs exert pivotal roles in the formation, development and maintenance of the vascular and lymphatic vessels. READ MORE