Search for dissertations about: "neuroplasticity"
Showing result 11 - 15 of 24 swedish dissertations containing the word neuroplasticity.
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11. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease
Abstract : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. READ MORE
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12. Synaptic plasticity in drug abuse disorders : studies of the human post-mortem brain
Abstract : Drug addiction is a chronic disorder characterized by craving and compulsive drug use despite adverse consequences and high rates of relapse during periods of abstinence. Therapeutic interventions for most addiction disorders are limited today, partly because the underlying neurobiology is still unknown. READ MORE
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13. Transcriptional dysregulation in L-DOPA-induced dyskinesia
Abstract : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. READ MORE
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14. Effects of PGC1a-induced exercise adaptations in muscle on plasticity and recovery mechanisms in the CNS
Abstract : In this thesis, we sought to determine if muscle-derived exercise-induced signaling via PGC-1α muscle activation influences neuroplasticity under physiological or pathophysiological conditions. For this purpose, transgenic mice with muscle-specific overexpression of PGC-1α that display an endurance exercise muscle phenotype were evaluated in models of cranial irradiation and photothrombotic stroke, as well as in aging and in a voluntary running paradigm. READ MORE
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15. On stroke risk in type 2 diabetes : focus on glycemic control, insulin resistance, obesity and recovery
Abstract : Background: People with type 2 diabetes (T2D) have an increased risk of cardiovascular disease. In this thesis the focus is on stroke with different aspects of aims, e.g. READ MORE