Search for dissertations about: "neuroprotection"

Showing result 16 - 20 of 81 swedish dissertations containing the word neuroprotection.

  2. 16. Toward a restorative therapy for Parkinson´s disease. Studies on the functional efficacy of intracerebral fetal cell transplants and GDNF delivery

    Author : Christian Winkler; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; Neurologi; neuropsykologi; neurofysiologi; neurophysiology; dyskinesia; L-DOPA; behaviour; transplantation; neuroprotection; GDNF; substantia nigra; striatum;

    Abstract : Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as L-DOPA-induced dyskinesia. READ MORE

  4. 17. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Author : Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Keywords : Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Abstract : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. READ MORE

  5. 18. Neuroprotection and neurogenesis after experimental stroke

    Author : Andreas Arvidsson; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stereology; rat; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; BrdU; immunohistochemistry; in situ hybridization; subventricular zone; striatum; dentate gyrus; neuronal replacement; neuronal survival; Focal cerebral ischemia; glial cell line-derived neurotrophic factor;

    Abstract : In this thesis, two potential endogenous mechanisms for neuronal survival and repair have been investigated in a rat model of stroke, middle cerebral artery occlusion (MCAO): signaling of the GDNF family of neurotrophic factors, and neurogenesis from endogenous progenitor cells. As determined by in situ hybridization for GDNF family ligand and receptor genes, MCAO caused widespread upregulation of both components of the functional GDNF receptor, c-Ret and GFRalpha1, indicating that GDNF may be a survival signal in stroke. READ MORE

  6. 19. Trophic factors, neuroprotection and spinal cord repair

    Author : Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Abstract : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. READ MORE

  7. 20. Neuroprotection and axonal regeneration after peripheral nerve injury

    Author : Dag Welin; Lev N. Novikov; Lars B. Dahlin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dorsal root ganglion; Motoneuron; Axonal reaction; Peripheral nerve injury; Nerve regeneration; N-acetylcysteine; Hand surgery; Handkirurgi; Anatomy; Anatomi; anatomi; Human Anatomy; handkirurgi; hand surgery;

    Abstract : Following microsurgical reconstruction of injured peripheral nerves, severed axons are able to undergo spontaneous regeneration. However, the functional result is always unsatisfactory with poor sensory recovery and reduced motor function. READ MORE