Advanced search

Showing result 1 - 5 of 41 swedish dissertations matching the above criteria.

2. 1. A Molecular Approach for Investigation of the Prevalence and Neurotoxin Formation of Clostridium botulinum in Food Safety Assessment

   Author : Maria Lövenklev; Teknisk mikrobiologi; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; neurotoxin gene expression; neurotoxin; food safety assessment; food preservation; Clostridium botulinum; enrichment PCR; Food and drink technology; qRT-PCR; Livsmedelsteknik; prevalence;

   Abstract : In the development of new food products, more knowledge is needed about the occurrence and quantity of food-borne pathogens in the food chain to be able to implement effective control measures and assure food safety. In addition, improved understanding of how environmental factors and food preservatives effect the microbial virulence expression in foods will enable the formulation of new strategies for food preservation and risk assessment. READ MORE

4. 2. Amperometric biosensors of food analysis relevance: Emphasis on the neurotoxin beta-ODAP in grass pea

   Author : Yirgalem Yigzaw; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Elektrokemi; Electrochemistry; Analytisk kemi; Analytical chemistry; neurotoxin; Amperometric biosensors; Lathyrus sativus;

   Abstract : Enzyme-based amperometric biosensors have been developed and characterized in flow systems for a variety of analytes such as [beta]-N-oxalyl-[alfa],[beta]-diamionpropionic acid ([beta]-ODAP), L-glutamate, glucose, lactate, and sucrose, that have food analysis relevance. The principle of enzyme "wiring" using polymeric mediators poly(1-vinylimidazole) {(Os-4, 4' dimethylbipyridyl)2Cl3+/2+} and poly(4-vinlypyridine {Os(N,N'-dimethyl-2,2'-biimidazole)3}3+/2+ has been employed in most of the sensors developed, which resulted in the fabrication of sensitive, stable and reproducible biosensors with carbonaceous electrodes (spectrographic graphite and glassy carbon). READ MORE

5. 3. Detection, transfer and role of an environmentally spread neurotoxin (BMAA) with focus on cyanobacteria and the Baltic Sea region

   Author : Lotta Berntzon; Birgitta Bergman; Geoffrey Codd; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; β-N-methylamino-L-alanine; BMAA; cyanobacteria; Baltic Sea; blooms; neurotoxin; neurodegenerative diseases; amyotrophic lateral sclerosis; ALS; nitrogenase; nitrogen fixation; Plant Physiology; växtfysiologi;

   Abstract : β-N-methylamino-L-alanine (BMAA) is one of the more recently discovered bioactive compounds produced by cyanobacteria. BMAA is a non-protein amino acid reported present in human brain tissues of patients deceased from a neurodegenerative disease, such as Alzheimer´s disease or amyotrophic lateral sclerosis (ALS). READ MORE

6. 4. β-N-methylamino-L-alanine (BMAA)-induced neurotoxicity : Studies in vitro and in vivo

   Author : Lisa Ersson; Malin Andersson; Eva B Brittebo; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BMAA; neurotoxin; neurodegeneration; cellular transport; metabolic profiling; protein-association; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : β-N-methylamino-L-alanine (BMAA) is a neurotoxic non-proteinogenic amino acid produced naturally by cyanobacteria, diatoms and dinoflagellates and it has been detected in samples from fresh and marine water from all over the world. It can bioaccumulate in fish and shellfish, and has a potential to biomagnify in a terrestrial food chain. READ MORE

7. 5. Structural and functional studies of a novel Botulinum neurotoxin and of MTH1

   Author : Linda Henriksson; Pål Stenmark; Maria Selmer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Botulinum neurotoxin; botulism; cancer; gene cluster; molecular structures; MTH1; NTNH; oxidised nucleotides; progenitor complex; protein expression; protein purification; X-ray crystallography; Biochemistry; biokemi;

   Abstract : X-ray crystallography visualizes the three dimensional molecular structures of proteins at atomic resolution. Seeing the molecular structure of a biomedically interesting protein enables a higher understanding of its function. READ MORE