Search for dissertations about: "neurotrophin-3"

Showing result 1 - 5 of 24 swedish dissertations containing the word neurotrophin-3.

2. 1. Role of Endogenous BDNF and NT3 for Synaptic Transmission and Plasticity in the Dentate gyrus

   Author : Klara Olofsdotter; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; dentate gyrus; GABA; glutamate; synaptic transmission; synaptic plasticity; Brain-derived neurotrophic factor; neurotrophin 3; Neurologi; neurophysiology; neuropsychology; Neurology; electrophysiology; neurofysiologi; neuropsykologi;

   Abstract : The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. READ MORE

4. 2. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

   Author : Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
   Keywords : neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

   Abstract : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. READ MORE

5. 3. Genetic aspects on schizophrenia and cerebrospinal fluid monoamine metabolites : focus on association studies with candidate genes

   Author : Erik Jönsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : association study; schizophrenia; DNA polymorphisms; dopamine receptors DRD2; DRD3; DRD4 ; tyrosine hydroxylase; tryptophan hydroxylase; catechol-O-methyltransferase; neurotrophin-3; ciliary neurotrophic factor; healthy subjects; cerebrospinal fluid;

   Abstract : Schizophrenia is a syndrome with psychotic symptoms. The pathogenesis of schizophrenia most likely reflects brain abnormalities and heritable components are present. The principal objective of the present thesis was to investigate some possible genetic influences in the genesis or pathophysiology of schizophrenia. READ MORE

6. 4. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

   Author : Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

   Abstract : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. READ MORE

7. 5. Mechanisms of Hyperexcitability in the Kindling Model of Epilepsy

   Author : Eskil Elmer; Sektion IV; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; Plasticity; Dentate gyrus; Mossy fibers; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Epilepsy is a syndrome characterized by recurring attacks of sudden, excessive and synchronous discharge in populations of cerebral neurons. Kindling is an animal model for complex partial epilepsy, and is particularly useful for studies on the development of the abnormal excitability underlying the generation and spread of epileptic seizures. READ MORE