Search for dissertations about: "neutrophil extracellular traps"

Showing result 11 - 15 of 31 swedish dissertations containing the words neutrophil extracellular traps.

2. 11. Neutrophil extracellular traps : function in infectious and non-Infectious conditions

   Author : Beatrice Lazzaretto; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Neutrophil extracellular traps (NETs) are composed of a backbone of chromatin, decorated with microbicidal peptides and proteolytic enzymes, and are used by neutrophils as a weapon against pathogens. Since their initial discovery in 2004, NETs have challenged scientists in terms of the nature of the triggers and the mechanisms of neutrophil release of NETs, as well as the implication of these extracellular structures in infectious and non-infectious human diseases. READ MORE

4. 12. Neutrophils and extracellular traps in abdominal sepsis

   Author : Ling Tao Luo; Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Abdominal sepsis is associated with changes in systemic inflammation response and coagulation homeostasis. Excessive neutrophil activation is a key regulator in both pro-inflammatory immune response and septic lung injury. Neutrophil-derived DNA may form extracellular traps in response to invading pathogens. READ MORE

5. 13. Neutrophil extracellular traps as potential therapeutic targets to prevent tumor-induced organ failure and metastasis

   Author : Melanie Herre; Anna-Karin Olsson; Jessica Cedervall; Peetra Magnusson; Benoit Ho-Tin-Noé; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neutrophil extracellular traps; NETs; cancer; metastasis; inflammation; organ dysfunction; thrombosis; Oncology; Onkologi;

   Abstract : Cancer does not only affect surrounding tissues, but also leads to complications at distant sites. The reason for this is that tumors secrete factors and prime cells that travel through the body, making cancer a systemic disease. In fact, cancer death is mostly caused by systemic complications such as metastasis, organ failure or thrombosis. READ MORE

6. 14. Innate immune responses to Mycobacterium tuberculosis infection : How extracellular traps and trained immunity can restrict bacterial growth

   Author : Clara Braian; Maria Lerm; Olle Stendahl; Parasa Venkata Ramanarao; Nordenfelt Pontus; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, and the cause of 1.5 million deaths in 2018. During a pulmonary TB infection, the bacterium reaches the lungs and is phagocytosed by cells of the innate immune system, primarily macrophages. READ MORE

7. 15. Complement in Autoimmunity - the importance of clearing waste

   Author : Jonatan Leffler; Malmö Proteinkemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; annexins; apoptosis; Complement system; neutrophil extracellular traps; systemic lupus erythematosus; C1q; factor H; histones;

   Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease where improperly cleared apoptotic cells and neutrophil extracellular traps (NETs) induce an autoimmune response. Complement is crucial to prevent SLE by tailoring immune responses and opsonizing dead cells but may also induce inflammation and tissue damage once the disease is initiated. READ MORE