Search for dissertations about: "new drug 2016"

Showing result 1 - 5 of 56 swedish dissertations containing the words new drug 2016.

  2. 1. Intracellular unbound drug concentrations : Methodology and application for understanding cellular drug exposure

    Author : André Mateus; Per Artursson; Pär Matsson; José A. G. Morais; Jeff Krise; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular unbound drug concentrations; free drug; drug binding; drug transport; drug accumulation; cellular drug response; drug target engagement; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. READ MORE

  4. 2. Towards new computational tools for predicting toxicity

    Author : Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

    Abstract : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. READ MORE

  5. 3. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers

    Author : Malin Morin Zetterberg; Katarina Edwards; Jonas Bergquist; Ana Maria Carmona-Ribeiro; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; model membranes; drug delivery; drug partitioning; antimicrobial peptides; nanocarriers; cryo-TEM; polymer-stabilized bilayer disks; Chemistry with specialization in Physical Chemistry; Kemi med inriktning mot fysikalisk kemi;

    Abstract : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. READ MORE

  6. 4. Thiol-Ene CHemistry and Dopa-Functional Materials towards Biomedical Applications

    Author : Kristina Olofsson; Anders Hult; Michael Malkoch; Anders Daugaard; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Thiol-ene chemistry; DOPA; biomedical; UV; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Abstract : Thiol-ene chemistry is versatile and efficient and can be used as a powerful tool in polymer synthesis. In this thesis, the concept of thiol-ene chemistry has been central, where it has been explored as a tool for the synthesis of well-defined hydrogels and dopa-functional materials towards biomedical applications; such as hydrogels, primers for adhesive fixation of bone fractures, self-healing gels, and micelles for drug-delivery. READ MORE

  7. 5. Potential New Drugs in Lymphoma

    Author : Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Abstract : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). READ MORE