Search for dissertations about: "new drug 2016"

Showing result 11 - 15 of 56 swedish dissertations containing the words new drug 2016.

  2. 11. Applications of in situ proximity ligation assays for cancer research and diagnostics

    Author : Liza Löf; Masood Kamali-Moghaddam; Ulf Landegren; J.Paul Robinson; Uppsala universitet; []
    Keywords : Cancer; Diagnostics; Research; Prognostics; Method development; Flow cytometry; Drug delivery; Molekylär medicin; Molecular Medicine;

    Abstract : In the field of cancer research and diagnostics it is crucial to have reliable methods for detecting molecules involved in the disease. New and better methods for diagnostics, prognostics and drug delivery therefore remain a permanent aim. READ MORE

  4. 12. Submicron Calcium Phosphate Spheres for Biomedical Applications : Synthesis and Use

    Author : Tao Qin; Håkan Engqvist; Fredrik Nikolajeff; Jie Huang; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; calcium phosphate; spheres; dentinal hypersensitivity; drug release; tooth bleaching;

    Abstract : Calcium phosphate spheres as biomaterials have been attracting attention in recent years. Calcium phosphate occurs naturally in bone, and a hollow structure could be advantageous for drug loading and release. READ MORE

  5. 13. Optimisation of Clinical Trials using Bayesian Decision Theory

    Author : Sebastian Jobjörnsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; decision theory; drug regulation; ; Bayesian statistics; subgroup analysis; clinical trials; health economics; multiple testing; decision theory;

    Abstract : A decision maker confronted with the task of designing a clinical trial has to consider a multitude of aspects. Large trials lead to more evidence,which in turn makes it less likely that harmful decisions are taken when deciding on future treatments for patients. READ MORE

  6. 14. Protein Folding Activity of the Ribosome and Its Implication in Prion Processes

    Author : Yanhong Pang; Suparna Sanyal; Patricia L. Clark; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein folding; Prion disease; Antiprion drug; Competitive inhibition; PFAR; Amyloid; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : How the linear protein chains fold into their three-dimensional active conformation is one of the remaining puzzles of modern science. Other than molecular chaperones, ribosome - the cellular protein synthesis machinery, has also been implicated in protein folding. READ MORE

  7. 15. Real-Time Monitoring of Healthcare Interventions in Routine Care : Effectiveness and Safety of Newly Introduced Medicines

    Author : Thomas Cars; Johan Sundström; Björn Wettermark; Martin Neovius; Til Stürmer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electronic Health Records; Comparative Effectiveness Research; Comparative Safety Research; Sequential drug monitoring; propensity score; real-world data; infliximab; TNF-inhibitors; dronedarone; amiodarone; flecainide; Farmakoepidemiologi; Pharmacoepidemiology;

    Abstract : Before market authorization of new medicines, their efficacy and safety are evaluated using randomized controlled trials. While there is no doubt about the scientific value of randomized trials, they are usually conducted in selected populations with questionable generalizability to routine care. READ MORE