Search for dissertations about: "new drug 2016"

Showing result 16 - 20 of 56 swedish dissertations containing the words new drug 2016.

  2. 16. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption

    Author : Andrea deBejczy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol dependence; mirtazapine; varenicline; org 25935; alcohol markers; phosphatidylethanol; randomized controlled clinical trials RCT ; treatment; glycine transporter inhibitor; nAChR;

    Abstract : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. READ MORE

  4. 17. Antiretroviral drug resistance and treatment outcomes of human immunodeficiency virus type-1 : implications for low and middle income countries

    Author : Amanda Häggblom; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : My thesis contains comprehensive studies of antiretroviral treatment (ART) naïve and experienced patients from the beginning of the Swedish HIV-1 epidemic. Paper I was the first study to describe the ART usage and occurrence acquired drug resistance mutations (DRM) at a population level in Sweden over time and we used data derived between 1997-2011. READ MORE

  5. 18. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

  6. 19. Quantitative analysis of mass spectrometry proteomics data : Software for improved life science

    Author : Johan Teleman; Institutionen för immunteknologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; computational proteomics; bioinformatics; life science; data complexity; algorithms; mass spectrometry;

    Abstract : The rapid advances in life science, including the sequencing of the human genome and numerous other techiques, has given an extraordinary ability to aquire data on biological systems and human disease. Even so, drug development costs are higher than ever, while the rate of new approved treatments is historically low. READ MORE

  7. 20. Tumor acidosis in malignant progression and therapy

    Author : Paola Pellegrini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer still represents one of the leading causes of death despite the advances achieved during the past years. Improving the outcome of cancer patients requires the identification of more affective therapeutic strategies and a better understanding of the molecular mechanisms involved in the progression of the disease. READ MORE