Search for dissertations about: "new molecular entities"

Showing result 1 - 5 of 29 swedish dissertations containing the words new molecular entities.

  2. 1. RNA-mediated virulence gene regulation in the human pathogen Listeria monocytogenes

    Author : Edmund Loh; Jörgen Johansson; Nancy Freitag; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Listeria monocytogenes; virulence; ncRNAs; PrfA; 5´-UTRs; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Gram-positive human pathogen Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. The majority of its virulence genes are encoded on a 9-kb pathogenicity island and are controlled by the transcriptional activator PrfA. READ MORE

  4. 2. Composite Materials in Molecular Imprinting Technology

    Author : Ecevit Yilmaz; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; immobilized template; molecularly imprinted polymer; composite material; polymerization method; heterogeneous imprinting; surface; morphology; Polymer technology; Polymerteknik; biopolymers;

    Abstract : Molecularly imprinted polymers (MIPs) are artificial plastic materials that mimic antibodies or enzymes. Like natural antibodies or enzymes, molecularly imprinted polymers can selectively bind target molecules or can promote catalytic reactions. READ MORE

  5. 3. Molecular Approaches to Explore Drug-Target Interactions

    Author : Abdullah Al-Amin; Ulf Landegren; Christopher Schofield; Uppsala universitet; []
    Keywords : Drug discovery; target engagement; target engagement-mediated amplification; cellular thermal shift assay; proximity extension assay; in situ PLA; high-content imaging; Molekylär medicin; Molecular Medicine;

    Abstract : Improved means to assess the clinical potential of drug candidates can critically influence development of new therapeutic entities, a central aim in medical life science. Drug discovery and development relies on construction and selection of small organic compounds or biological agents that bind targets of interest. READ MORE

  6. 4. In Vitro Drug Sensitivity and Apoptosis in Chronic Lymphocytic Leukemia

    Author : Maria Norberg; Richard Rosenquist; Anna Åleskog; Elin Lindhagen; Gerard Tobin; Per-Ola Andersson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; in vitro drug sensitivity; apoptosis; prognostic markers; Clinical genetics; Klinisk genetik; Haematology; Hematologi; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; MEDICINE; MEDICIN; Medical genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap; Clinical Genetics; Klinisk genetik; Molekylär genetik; Molecular Genetics; Medical Genetics; Medicinsk genetik; Molekylär medicin; Molecular Medicine;

    Abstract : Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy displaying varying clinical outcome, where molecular markers today can divide patients into prognostic subgroups. Despite the introduction of new agents for treatment, remissions are usually not sustained in CLL and resistance towards treatment can partly be explained by aberrant apoptosis. READ MORE

  7. 5. Ribosomal proteins L5 and L15 : Functional characterisation of important features, in vivo

    Author : Ivailo Simoff; Odd Nygård; Gustavo Nader; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; cellbiologi; Cellbiology;

    Abstract : Protein synthesis is a highly regulated and energy consuming process, during which a large ribonucleoprotein particle called the ribosome, synthesizes new proteins. The eukaryotic ribosome consists of two unequal subunits called: small and large subunits. Both subunits are composed of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins). READ MORE