Search for dissertations about: "next-generation sequencing"

Showing result 21 - 25 of 177 swedish dissertations containing the words next-generation sequencing.

  2. 21. Genome Evolution of Neurospora tetrasperma

    Author : Yu Sun; Hanna Johannesson; Siv Andersson; Toni Gabaldon; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurospora tetrasperma; next-generation sequencing; introgression; intron; chromosomal inversion; codon usage; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : In this thesis work, I have used a comparative genomics approach to study a fungal model organism, Neurospora tetrasperma. My specific focus has been on genomic introgression, intron evolution, chromosomal structural rearrangements and codon usage. READ MORE

  4. 22. Rule-Based Approaches for Large Biological Datasets Analysis : A Suite of Tools and Methods

    Author : Marcin Kruczyk; Jan Komorowski; Joaquin Dopazo; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Rough sets; peak finding; gliomas; Alzheimer disease; STAT3; machine learning; feature selection; next generation sequencing;

    Abstract : This thesis is about new and improved computational methods to analyze complex biological data produced by advanced biotechnologies. Such data is not only very large but it also is characterized by very high numbers of features. READ MORE

  5. 23. The Nucleosome as a Signal Carrying Unit : From Experimental Data to Combinatorial Models of Transcriptional Control

    Author : Stefan Enroth; Jan Komorowski; Claes Wadelius; Rickard Sandberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Next generation sequencing; Nucleosome; Histone modification; Transcriptional regulation; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik; Bioinformatik; Bioinformatics;

    Abstract : The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. READ MORE

  6. 24. Genetic studies of craniosynostosis with focus on syndromic forms

    Author : Alexandra Topa; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cranial; suture; genetic; diagnostic; next generation sequencing;

    Abstract : Craniosynostosis (CS) represents the premature closure of skull sutures and affects ~1 in 2500 children. Untreated CS can lead to significant complications in craniofacial and psychomotor development. The only treatment available is surgical and requires access to highly specialized healthcare. READ MORE

  7. 25. Proximity Ligation Assays for Disease Biomarkers Analysis

    Author : Rachel Yuan Nong; Ulf Landegren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; blood biomarkers; protein interactions; pathway analysis; single molecule; next-generation sequencing; Molekylär medicin; Molecular Medicine;

    Abstract : One of the pressing needs in the field of disease biomarker discovery is new technologies that could allow high performance protein analysis in different types of clinical material, such as blood and solid tissues. This thesis includes four approaches that address important limitations of current technologies, thus enabling highly sensitive, specific and parallel protein measurements. READ MORE