Search for dissertations about: "nitazoxanide"

Found 4 swedish dissertations containing the word nitazoxanide.

  1. 1. New preclinical strategies for characterization and development of anticancer drugs

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Henning Karlsson; Peter Nygren; Rolf Larsson; Mattias Belting; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; spheroids; green fluorescent protein; VLX50; VLX60; VLX600; nitazoxanide; radiation; radiosensitizer; Oncology; Onkologi;

    Abstract : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. READ MORE

  2. 2. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Wojciech Senkowski; Mårten Fryknäs; Rolf Larsson; Peter Nygren; Mats Gustafsson; Krister Wennerberg; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; spheroids; high-throughput screening; nitazoxanide; OXPHOS; gene expression profiling; statins; drug repositioning; 3D cell culture; quiescent cells; Medical Science; Medicinsk vetenskap;

    Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE

  3. 3. Drug Repositioning for Cancer Treatment Novel Candidate Identification Strategies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

    Abstract : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. READ MORE

  4. 4. Development of therapeutic strategies for quiescent tumor cell populations

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Xiaonan Zhang; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Phenotypic screening is an effective approach to the discovery of small-molecule drugs. In this thesis, I have used cancer cells grown as 3D microtissues (multicellular spheroids) to study the effect of anticancer drugs and as drug discovery tools. READ MORE