Search for dissertations about: "nitric oxide in diabetes"

Showing result 1 - 5 of 59 swedish dissertations containing the words nitric oxide in diabetes.

  2. 1. Regulation of cytokine-induced nitric oxide production in insulin-producing cells

    Author : Malin Flodström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin-producing cells; cytokines; nitric oxide; inducible nitric oxide synthase; nuclear factor-kappaB; interferon regulatory factor-1; arginine; citrulline; argininosuccinate synthetase; insulin release; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Cytokine-induced expression of the inducible form of nitric oxide synthase (iNOS) and production of nitric oxide (NO) may contribute to pancreatic β-cell damage during the development of type 1 diabetes. iNOS catalyses the conversion of arginine into citrulline and NO, a reaction regulated by the amount of expressed iNOS enzyme and by the cellular availability of arginine. READ MORE

  4. 2. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    Author : Annika K. Andersson; Stellan Sandler; Nils Welsh; Décio L. Eizirik; Nils Billestrup; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. READ MORE

  5. 3. Prevention of type 1 diabetes mellitus in experimental studies

    Author : Maria Holstad; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. READ MORE

  6. 4. Diabetes-induced Alterations in Renal Microcirculation and Metabolism

    Author : Fredrik Palm; Per Liss; Peter Hansell; Per-Ola Carlsson; Gerald DiBona; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; diabetes mellitus; kidney; nephropathy; oxygen tension; haemodynamic; nitric oxide; oxygen consumption; radical oxygen species; polyol pathway; Fysiologi; Physiology; Fysiologi;

    Abstract : Diabetes-induced renal complications, i.e. diabetes nephropathy, are a major cause of morbidity and mortality. The exact mechanism mediating the negative influence of hyperglycaemia on renal function is unclear, although several hypotheses have been postulated. READ MORE

  7. 5. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress

    Author : Patrik Persson; Fredrik Palm; Peter Hansell; Bengt Rippe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; diabetic nephropathy; glomerular filtration rate; renal blood flow; insulin; renal hemodynamics; micropuncture; oxygen; NADPH-oxidase; apocynin; streptozotocin; l-arginine; CGS21680; rats; mice; Physiology; Fysiologi; Medical Science; Medicinsk vetenskap;

    Abstract : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. READ MORE