Search for dissertations about: "nociception"
Showing result 1 - 5 of 48 swedish dissertations containing the word nociception.
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1. Bioactive Lipids in Nociception
Abstract : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. READ MORE
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2. Spotting pain in the brain. Towards a useful animal model of pain
Abstract : Current models of pain in conscious animals usually scores nocifensive responses. However, it is still unclear to what extent these responses are related to, for instance, the sensory discriminative or affective aspects of pain. READ MORE
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3. Acetylcholine in Spinal Pain Modulation : An in vivo Study in the Rat
Abstract : The spinal cord is an important component in the processing and modulation of painful stimuli. Nerve signals from the periphery are relayed and further conducted to the brain (nociception) in the spinal cord, and the most essential modulation of painful information (antinociception) occurs here. READ MORE
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4. Effects of repetitive work on proprioception and of stretching on sensory mechanisms : implications for work-related neuromuscular disorders
Abstract : The aims of the thesis were (i) to investigate the impact of repetitive low-intensity work exposure on proprioception and (ii) to examine effects of muscle stretching (especially sensory effects and effects on muscle nociception) and to relate its application to the prevention, alleviation and/or treatment of work-related neuromuscular disorders. The effects of low-intensity repetitive work on the shoulder proprioception were tested in healthy subjects. READ MORE
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5. Somatosensory Circuits in the Central Nervous System
Abstract : Spinal glycinergic neurons prevent spontaneous sensations of pain and itch, and development of persistent pain and itch conditions. The glycine receptor alpha 3 subunit (GLRA3) is suggested to be involved in certain inflammatory models, but not in acute nociception. READ MORE