Search for dissertations about: "node-negative"

Showing result 11 - 15 of 29 swedish dissertations containing the word node-negative.

  2. 11. Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma

    Author : Iva Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary cutaneous melanoma; chronic sun-damage; chronic sun-damage skin; gene expression profiling; immunohistochemistry; tertiary lymphoid structures;

    Abstract : Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage II. Correct identification of the patients at high risk for progressive disease who will benefit from the treatment is crucial. READ MORE

  4. 12. Predictors of Lymph Node Metastasis in Primary Breast Cancer - Risk Models for Tailored Axillary Management

    Author : Looket Dihge; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Axillary lymph node dissection; Sentinel lymph node biopsy; Ultrasonography; Nomogram; Artificial neural network; Gene Expression; Prediction model;

    Abstract : Most patients with breast cancer present with low-risk tumors, node-negative disease, and excellent prognosis. For these patients, routine axillary nodal staging by sentinel lymph node biopsy (SLNB) has no therapeutic benefit. For patients with limited sentinel lymph node metastasis, completion axillary nodal dissection is controversial. READ MORE

  5. 13. Long-term risk for fatal and distant metastatic disease in women with ER-positive breast cancer

    Author : Huma Dar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is a major cause of mortality among women worldwide, with estrogen receptor (ER)-positive disease breast cancer being the most common type of breast cancer. A unique feature of ER-positive breast cancer is the continuous long-term risk of distant metastatic spread and fatal disease. READ MORE

  6. 14. Sentinel lymph node biopsy in breast cancer : aspects on indications and limitations

    Author : Linda Holmstrand Zetterlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Axillary lymph node status is the most important prognostic factor in breast cancer. Sentinel lymph node biopsy (SLNB) was introduced in the late 1990s and has replaced axillary lymph node dissection (ALND) as the gold standard axillary nodal staging procedure in early breast cancer due to higher accuracy and less morbidity compared with ALND. READ MORE

  7. 15. Sentinel Node Biopsy in Breast Cancer : Clinical and Immunological Aspects

    Author : Jana de Boniface; Leif Bergkvist; Annika Håkansson; Omgo Nieweg; Uppsala universitet; []
    Keywords : Surgery; breast cancer; tumour immunology; sentinel node biopsy; CD3-zeta; CD28; Kirurgi;

    Abstract : The most important prognostic factor in breast cancer is the axillary lymph node status. The sentinel node biopsy (SNB) is reported to stage the axilla with an accuracy > 95 % in early breast cancer. Tumour-related perturbation of T-cell function has been observed in patients with malignancies, including breast cancer. READ MORE