Search for dissertations about: "nogo"

Showing result 1 - 5 of 16 swedish dissertations containing the word nogo.

  2. 1. On Nogo signaling regulation

    Author : Alexandra Trifunovski; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nogo; Nogo receptor; regulation; neurotrophin; Lingo-1; p75NTR; Troy; synaptic plasticity;

    Abstract : As neuronal development enters its final stages, axon growth becomes restricted. This lack of regenerative capacity is partly due to the non-permissive environment of growth inhibitory proteins. Three such proteins, Nogo, OMgp and MAG bind to the same receptor, the Nogo receptor (NgR) and induce growth cone collapse and axon growth inhibition. READ MORE

  4. 2. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

    Author : Zuzanna Kurowska; Neural plasticitet och reparation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

    Abstract : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. READ MORE

  5. 3. On nogo receptors, plasticity and lasting memories

    Author : Tobias Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The central nervous system has very limited ability to repair itself after injury but has been shown to exhibit remarkable experience-driven structural plasticity at the synaptic level. These changes correlate strongly with behavioral performance and are thought to underlie learning and memory. READ MORE

  6. 4. Regulations of neuronal plasticity by the Nogo system

    Author : Gabriella Smedfors; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our brain has a lifelong capacity to create new memories, to learn and to adapt. This is due to the ability of neurons to modify their signaling depending on the situation to which the nervous system is exposed. The neurons of the CNS have despite this plasticity, a very limited ability to grow and recover if damaged. READ MORE

  7. 5. Plasticity and Inflammation following Traumatic Brain Injury

    Author : Anders Hånell; Niklas Marklund; Lars Hillered; Nikolaus Plesnila; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic Brain Injury; plasticity; inflammation; Nogo receptor; EphA4; IL-1β; Neurosurgery; Neurokirurgi; Neuroscience; Neurovetenskap;

    Abstract : Traumatic Brain Injury (TBI) mainly affects young persons in traffic accidents and the elderly in fall accidents. Improvements in the clinical management have significantly improved the outcome following TBI but survivors still suffer from depression, memory problems, personality changes, epilepsy and fatigue. READ MORE