Search for dissertations about: "non mevalonate pathway"

Showing result 1 - 5 of 8 swedish dissertations containing the words non mevalonate pathway.

  2. 1. Inhibition of the mevalonate pathway in C. elegans: Consequences and implications

    Author : Parmida Ranji; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mevalonate pathway; C. elegans; atfs-1; mitochondrial unfolded response UPR ;

    Abstract : The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on the mevalonate pathway using C. READ MORE

  4. 2. Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis

    Author : Lena M Henriksson; Torsten Unge; Sherry L. Mowbray; Barbara Seaton; Uppsala universitet; []
    Keywords : Molecular biology; Mycobacterium tuberculosis; Rv0009; peptidyl-prolyl cis-trans isomerase; Rv2870c; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; non-mevalonate pathway; DOXP MEP pathway; X-ray crystallography; Molekylärbiologi;

    Abstract : Mycobacterium tuberculosis, the causative pathogen of tuberculosis, currently infects one-third of the world’s population, resulting in two million deaths annually. This clearly shows that tuberculosis is one of the most serious diseases of our times. READ MORE

  5. 3. Requirement for mevalonate-derived lipids in cell proliferation : a study of the role of polyisoprenoid alcohols

    Author : Johan Wejde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mevalonic acid constitutes a key intermediate in the biosynthesis of a number of isoprenoid products. These metabolites include cholesterol and sterol-derived molecules, but also a large number of non-sterol isoprene derivatives. READ MORE

  6. 4. Novel Agonists and Antagonists of Platelet Receptors

    Author : Carl Högberg; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Platelets; P2Y12; SUCNR1; FPP; hypothermia;

    Abstract : Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. READ MORE

  7. 5. Novel Modes of Immune Activation in Anopheles gambiae and Drosophila melanogaster

    Author : Bo Lindberg; Ingrid Faye; Kenneth Vernick; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

    Abstract : Malaria is a disease of poverty and continues to plague a great part of the world’s population. An increased understanding of the interactions between the vector mosquito, the malaria parasite, and also the mosquito gut microbiota are pivotal for the development of novel measures against the disease. READ MORE