Search for dissertations about: "non-Smad"

Found 3 swedish dissertations containing the word non-Smad.

  2. 1. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    Author : Reshma Sundar; Marene Landström; Carl-Henrik Heldin; Petra Knaus; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Abstract : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. READ MORE

  4. 2. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Author : Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE

  5. 3. Molecular mechanisms for activation of non-canonical TGFβ pathways and their importance during prostate cancer progression

    Author : Anahita Hamidi; Marene Landstöm; Carl-Henrik Heldin; Ramin Massoumi; Uppsala universitet; []
    Keywords : TGFβ; AKT; PI3K; p85α; TRAF6; TAK1; NF-κB; Src; prostate cancer; PC-3U; cell migration; inflammation; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Prostate cancer is the most common invasive cancer diagnosed in men and a major and growing health problem in Western countries. Deregulation of different pathways has been implicated in progression of prostate cancer, namely nuclear factor kappa enhancer binding protein (NF-κB), transforming growth factor β (TGFβ), phosphoinositide 3ʹ-kinase/AKT (PI3K/AKT) and Src kinase pathways. READ MORE