Search for dissertations about: "non-covalent complexes"

Showing result 1 - 5 of 23 swedish dissertations containing the words non-covalent complexes.

  2. 1. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Author : Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE

  4. 2. Complexes of cell-penetrating peptides with oligonucleotides : Structure, binding and translocation in lipid membranes

    Author : Luis Daniel Ferreira Vasconcelos; Ülo Langel; William C. Wimley; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; oligonucleotide; transfection; non-covalent complexes; membrane interaction; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The fundamental element of life known to man is the gene. The information contained in genes regulates all cellular functions, in health and disease. The ability to selectively alter genes or their transcript intermediates with designed molecular tools, as synthetic oligonucleotides, represents a paradigm shift in human medicine. READ MORE

  5. 3. NMR Investigations of Host-Guest Complexes and Their Dynamic Properties

    Author : Zdenek Tosner; Jozef Kowalewski; Josef Stepanek; Klaus Muller; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; supramolecular chemistry; host-guest complexes; non-covalent interactions; nuclear magnetic resonance; molecular motion; C-13 relaxation; deuterium NMR; dipolar recoupling; Physical chemistry; Fysikalisk kemi;

    Abstract : This thesis discusses several different methods offered by solution and solid state nuclear magnetic resonance for investigation of host-guest complexes and their constituents. The presented methods were used especially (but not exclusively) to address rotational dynamics of the bound guest in different molecular systems. READ MORE

  6. 4. Bicyclo[3.3.1]nonanes as Scaffolds in Supramolecular Chemistry : From Host-Guest Systems to Hydrogen-Bonded Aggregates

    Author : Anna Lidskog; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; supramolecular chemistry; host-guest system; non-covalent interactions; hydrogen bonding; aromatic interactions; electrostatic interactions; synthetic receptors; self-assembly; nanotubes;

    Abstract : This thesis describes the use of bicyclo[3.3.1]nonane and its heteroanalogue 1,5- diazabicyclo[3.3. READ MORE

  7. 5. Lignin-carbohydrate complexes: Model compounds synthesis

    Author : Filip Nylander; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lignin-carbohydrate complex; lignin model compounds; lignocellulose;

    Abstract : In lignocellulose there is a recalcitrant interaction by covalent and non-covalent bonds called the lignin-carbohydrate complex. This interaction has been the subject of studies trying to unveil its chemical structure, to understand the mechanims involved in its formation and to determine its influence on practical applications such as the process of turning biomass into ethanol. READ MORE