Search for dissertations about: "non-esterified fatty acids"

Showing result 1 - 5 of 13 swedish dissertations containing the words non-esterified fatty acids.

  2. 1. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

    Author : Mariam Rodríguez-Lee; Göteborgs universitet; []
    Keywords : proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

    Abstract : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). READ MORE

  4. 2. Modelling of tolerance and rebound in normal and diseased rats

    Author : Christine Ahlström; Göteborgs universitet; []
    Keywords : feedback modelling; tolerance; rebound; pharmacokinetics; pharmacodynamics; dyslipidaemia; nicotinic acid; non-esterified fatty acids;

    Abstract : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. READ MORE

  5. 3. Molecular cloning and characterization of the murine acyl-CoA thioesterase CTE-I

    Author : Per J G Lindquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; fatty acid metabolism;

    Abstract : Mouse cytosolic type I acyl-CoA thioesterase (CTE-I) is a member of the type I family of acylCoA thioesterases. These enzymes hydrolyze acyl-CoAs to non-esterified fatty acids (NEFAs) and Coenzyme A (CoA-SH) and are strongly induced in rodent liver by a diverse group of compounds called peroxisome proliferators. READ MORE

  6. 4. Perilipin expression in the islets of Langerhans and Surface expression in the baculovirus/insect cell system

    Author : Jörgen Borg; Molekylär endokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biology; Biologi; lipotoxicity; beta-cell; perilipin; amino-terminal anchor; Baculovirus; surface display;

    Abstract : Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. READ MORE

  7. 5. Peroxisomal and mitochondrial enzymes involved in lipid metabolism : studies on function and regulation

    Author : Veronika Tillander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Fatty acids constitute a major part of the energy that we obtain from the diet and are also the principal source for mammals to store energy. To use the incoming or stored fatty acids as energy, the fatty acids needs to be metabolized of which the majority of fatty acids will be degraded by the mitochondrial β-oxidation system that in the end generates energy to the cell in the form of ATP. READ MORE