Search for dissertations about: "non-viral"

Showing result 16 - 20 of 27 swedish dissertations containing the word non-viral.

2. 16. Development of novel DNA vaccine and immunotherapeutic approaches

   Author : Maroof Hasan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is time to rethink, since more innovative approaches are needed for better control of infection and immunotherapy. READ MORE

4. 17. Oligonucleotide Complexes with Cell-Penetrating Peptides : Structure, Binding, Translocation and Flux in Lipid Membranes

   Author : Luis Daniel Ferreira Vasconcelos; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; Large unilamellar vesicle; Membrane perturbation; Endosomal escape; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : The ability of cell-penetrating peptides to cross plasma membranes has been explored for various applications, including the delivery of bioactive molecules to inhibit disease-causing cellular processes. The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. READ MORE

5. 18. Functional Cyclic Carbonate Monomers and Polycarbonates : Synthesis and Biomaterials Applications

   Author : Jonas Mindemark; Tim Bowden; Andrew Dove; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA condensation; gene delivery; ionomers; polyplexes; self-assembly; amphiphiles; biodegradable; biological applications of polymers; transfection; cyclic carbonate monomers; polycarbonates; semicrystalline polymers; click chemistry; triazoles; cycloaddition; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

   Abstract : The present work describes a selection of strategies for the synthesis of functional aliphatic polycarbonates. Using an end-group functionalization strategy, a series of DNA-binding cationic poly(trimethylene carbonate)s was synthesized for application as vectors for non-viral gene delivery. READ MORE

6. 19. EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

   Author : Liudmila Matskova; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus EBV ; Latent membrane protein 2A LMP2A . HECTdomain E3 ubiquitin ligase; Shb signaling scaffold. Akt kinase; Tyrosine phosphorylation.;

   Abstract : Over 90% of the adult human population carries Epstein-Barr Virus (EBV). EBV stays for life, striking a balance with the immune system. The virus evades immune elimination by severely restricting its own gene expression. The latent infection is established with the resting memory type B-cell as the reservoir. READ MORE

7. 20. Molecular characterization of the hepatitis C virus core protein

   Author : Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

   Abstract : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. READ MORE