Search for dissertations about: "nonlinear mixed effects"

Showing result 1 - 5 of 25 swedish dissertations containing the words nonlinear mixed effects.

  1. 1. Contributions to nonlinear mixed-effects modeling

    University dissertation from Göteborg : Chalmers University of Technology

    Author : Jacob Leander; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nonlinear mixed-effects models; stochastic differential equations; parameter estimation; extended Kalman filter; sensitivity equations;

    Abstract : The topic of this thesis is nonlinear mixed-effects models.A nonlinear mixed-effects model is a hierarchical regression model used to analyze measurements from several individuals simultaneously, which allows sharing of information between similar individuals. READ MORE

  2. 2. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Matts Kågedal; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE

  3. 3. Covariate Model Building in Nonlinear Mixed Effects Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jakob Ribbing; Uppsala universitet.; [2007]
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Abstract : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. READ MORE

  4. 4. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joakim Nyberg; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; robust design; optimizing drug development; population models; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. READ MORE

  5. 5. Methodology for Handling Missing Data in Nonlinear Mixed Effects Modelling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Åsa M. Johansson; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; population models; censored observations; missing covariates; missing dependent variable; missing data mechanism; missing completely at random MCAR ; missing at random MAR ; missing not at random MNAR ; estimation algorithms; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : To obtain a better understanding of the pharmacokinetic and/or pharmacodynamic characteristics of an investigated treatment, clinical data is often analysed with nonlinear mixed effects modelling. The developed models can be used to design future clinical trials or to guide individualised drug treatment. READ MORE