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Showing result 1 - 5 of 40 swedish dissertations matching the above criteria.
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1. Contributions to nonlinear mixed-effects modeling
Abstract : The topic of this thesis is nonlinear mixed-effects models. A nonlinear mixed-effects model is a hierarchical regression model used to analyze measurements from several individuals simultaneously, which allows sharing of information between similar individuals. READ MORE
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2. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology
Abstract : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. READ MORE
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3. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies
Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE
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4. Covariate Model Building in Nonlinear Mixed Effects Models
Abstract : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. READ MORE
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5. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models
Abstract : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. READ MORE