Search for dissertations about: "nonlinear mixed effects"

Showing result 16 - 20 of 40 swedish dissertations containing the words nonlinear mixed effects.

  2. 16. Applied Adaptive Optimal Design and Novel Optimization Algorithms for Practical Use

    Author : Eric Strömberg; Andrew Hooker; Mats Karlsson; Timothy Waterhouse; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nonlinear Mixed Effects Models; Pharmacometrics; Fisher Information Matrix; Approximation; Optimality Criterion; Parallelization; Model Based Adaptive Optimal Design; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : The costs of developing new pharmaceuticals have increased dramatically during the past decades. Contributing to these increased expenses are the increasingly extensive and more complex clinical trials required to generate sufficient evidence regarding the safety and efficacy of the drugs. READ MORE

  4. 17. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development

    Author : Anne-Gaëlle Dosne; Mats O. Karlsson; Rik Schoemaker; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; confirmatory trials; residual error modeling; parameter uncertainty; sampling importance resampling; model-averaging; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. READ MORE

  5. 18. Data-driven modeling of combination therapy in oncology

    Author : Tim Cardilin; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling; Nonlinear Mixed-Effects Models;

    Abstract : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. READ MORE

  6. 19. Oral eflornithine treatment of late-stage human African trypanosomiasis

    Author : Mikael Boberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

    Abstract : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. READ MORE

  7. 20. Pharmacometric Models to Improve Treatment of Tuberculosis

    Author : Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
    Keywords : pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. READ MORE