Search for dissertations about: "nonparametric linkage analysis"

Showing result 1 - 5 of 6 swedish dissertations containing the words nonparametric linkage analysis.

  2. 1. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Author : Lars Ängquist; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE

  4. 2. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis

    Author : Mikael Knutsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; affected sib-pair; linkage analysis; nonparametric linkage score; sib prevalence; statistical genetics; nonparametric linkage score;

    Abstract : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. READ MORE

  5. 3. Which Genes are Involved? - Statistical Planning and Analysis of Human Genetic Samples

    Author : Staffan Nilsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis consists of six papers related to the statistical planning and analysis of human genetic samples. The first four mainly concern statistical methodology, while the last two are applied papers in genetics and medicin. In paper A an alternative method of estimating the locus specific sibling relative risk .lambda. READ MORE

  6. 4. Genetic studies of atopic dermatitis

    Author : Maria Bradley; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atopic dermatitis; genome-wide linkage analysis; sib pairs; candidate genes; nonparametric linkage;

    Abstract : Known from ancient times, atopic dermatitis is now the most prevalent chronic inflammatory skin disease in Swedish children. This is the result of a marked increase over the past few decades. READ MORE

  7. 5. Investigation of genetic factors involved in colorectal cancer predisposition

    Author : Tatjana Djureinovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : colorectal cancer CRC ; hereditary colorectal cancer HCRC ; two-close relatives TCR ; linkage analysis; case-control;

    Abstract : Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the western world. Several hereditary CRC predisposing syndromes have been described and their genetic component has been elucidated. Taken together, these syndromes account for at most 5% of all CRC cases. READ MORE