Search for dissertations about: "nonparametric linkage"

Showing result 1 - 5 of 8 swedish dissertations containing the words nonparametric linkage.

2. 1. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

   Author : Lars Ängquist; Matematisk statistik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

   Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE

4. 2. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis

   Author : Mikael Knutsson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; affected sib-pair; linkage analysis; nonparametric linkage score; sib prevalence; statistical genetics; nonparametric linkage score;

   Abstract : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. READ MORE

5. 3. Nonparametric linkage power by simulations and multivariate normal approximations

   Author : Mikael Knutsson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : .... READ MORE

6. 4. Genetic studies of atopic dermatitis

   Author : Maria Bradley; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Atopic dermatitis; genome-wide linkage analysis; sib pairs; candidate genes; nonparametric linkage;

   Abstract : Known from ancient times, atopic dermatitis is now the most prevalent chronic inflammatory skin disease in Swedish children. This is the result of a marked increase over the past few decades. READ MORE

7. 5. Investigation of genetic factors involved in colorectal cancer predisposition

   Author : Tatjana Djureinovic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : colorectal cancer CRC ; hereditary colorectal cancer HCRC ; two-close relatives TCR ; linkage analysis; case-control;

   Abstract : Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the western world. Several hereditary CRC predisposing syndromes have been described and their genetic component has been elucidated. Taken together, these syndromes account for at most 5% of all CRC cases. READ MORE