Search for dissertations about: "normal tissue toxicity"
Showing result 1 - 5 of 46 swedish dissertations containing the words normal tissue toxicity.
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1. Modelling late toxicity in hypofractionated radiation therapy
Abstract : In hypofractionated radiation therapy (RT), the treatment is delivered by few fractions with high doses per fraction. This is in contrast to conventionally fractionated RT where the total dose is delivered in many fractions with low doses per fraction. READ MORE
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2. Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
Abstract : Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. READ MORE
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3. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications
Abstract : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. READ MORE
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4. Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment
Abstract : Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable patient benefits and is well tolerated. However, renal and bone marrow toxicity can become dose limiting and persisting. READ MORE
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5. Therapy with 177Lu-octreotate - pharmacokinetics, dosimetry and kidney toxicity
Abstract : 177Lu-octreotate is used for treatment of patients with somatostatin receptor expressing neuroendocrine tumors in some clinics using a standard schedule. Renal and bone marrow toxicity are the main limiting factors. READ MORE