Search for dissertations about: "norsertraline"

Found 1 swedish dissertation containing the word norsertraline.

2. 1. Transition Metal- and Enzyme-Catalyzed Reactions of Primary Amines and Allylic Alcohols : Powerful Tools in the Preparation of Pharmaceutically Important Compounds

   Author : Lisa K. Thalén; Jan-Erling Bäckvall; Dirk De Vos; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic kinetic resolution; racemization; catalysis; hydrogen transfer; kinetic resolution; norsertraline; alpha-methyl carboxylic acids; pipecoloxylidide; organisk kemi; Organic Chemistry;

   Abstract : Dynamic kinetic resolution (DKR) has been applied to primary amines utilizing a ruthenium catalyst and an (R)-selective lipase to provide the corresponding amides in up to 95% isolated yield and up to >99% ee. Further investigations of the chemoenzymatic DKR of amines show that it is general and can be applied to a wide range of amines. READ MORE