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Showing result 1 - 5 of 17 swedish dissertations matching the above criteria.

  2. 1. Palaeoenvironmental reconstructions from modern and ancient plant DNA

    Author : Kevin Nota; Laura Parducci; Love Dalén; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular palaeoecology; Ancient lake sediments; Post-glacial migration; Floral changes; Biology with specialization in Ecological Botany; Biologi med inriktning mot ekologisk botanik;

    Abstract : Palaeoecological studies on lake sediments and peat archives have provided fundamental knowledge about past environments, nevertheless, a lot remains to be learned. In this thesis, I focussed on plant ancient DNA extracted from sedimentary archives (sedaDNA), in combination with DNA from living trees with the aims of: (1) investigating different extraction methods and levels of inhibition in sediments, (2) investigating postglacial recolonisation history of Norway spruce in Fennoscandia, (3) comparing different sequencing and bioinformatic approaches to investigate past flora changes using sedaDNA and investigating past flora change in contrasting environments (southern Italy versus southern Sweden), and (4) communicating my work more broadly using art. READ MORE

  4. 2. Women and Biological Research Careers in Higher Education in Mozambique : A Case Study of Two Public Universities

    Author : Juvencio Manuel Nota; Gabriele Griffin; Anita Hussénius; Louise Morley; Uppsala universitet; []
    Keywords : women; biological research careers; higher education; institutional ethnography; inequality regimes; Gender Studies; Genusvetenskap;

    Abstract : The issue of women’s experiences in biological research careers in academia in Mozambique is under-researched. This lack of knowledge does not enable the country to design structural tools that can help women to overcome the obstacles and challenges they face and hence boost their career progression in academia. READ MORE

  5. 3. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis

    Author : Elisabeth Blom; Bengt Långström; Oleksiy Itsenko; Irina Velikyan; Farhad Karimi; Frank Rösch; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PET; nucleophilic 18F-fluorination; perfluoro; F-SPE; molecular design; 68Ga; chelators; DOTA; NOTA; microwave; halogen exchange; harmine; biotin; RGD; VEGF; CRP; Chemistry; Kemi; Organisk kemi; Organic Chemistry;

    Abstract : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. READ MORE

  6. 4. Site-specific labeling of affinity molecules for in vitro and in vivo studies

    Author : Anna Perols; Amelie Eriksson Karlström; Christian Hackenberger; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; molecular imaging; site-specific labeling; solid phase peptide synthesis; IgG-binding domains; photoconjugation.; Bioteknologi; Biotechnology;

    Abstract : The thesis is focused on site-specific labeling of affinity molecules for different applications where two types of binding proteins, Affibody molecules and antibodies, have been used. For the purpose of improving the properties of Affibody molecules for in vivo imaging, novel bi-functional chelators for radiolabeling using the radionuclide 111In were evaluated. READ MORE

  7. 5. Bombesin Antagonists for Targeting Gastrin-Releasing Peptide Receptor-Positive Tumors : Design, Synthesis, Preclinical Evaluation and Optimization of Imaging Agents

    Author : Zohreh Varasteh; Anna Orlova; Roger Schibli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bombesin; Gastrin-releasing peptide receptor GRPR ; Antagonist; Radionuclide molecular imaging;

    Abstract : This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers for the detection of gastrin-releasing peptide receptor (GRPR)-expressing tumors. The work is divided into three distinct parts: (1) the development of bombesin (BN) antagonist (RM26)-based imaging radiotracers for the detection of GRPR-expressing tumors using different positron emission tomography (PET) and single photon emission computed tomography (SPECT) radionuclides (68Ga, 18F and 111In), (2) the establishment of a method to monitor the ligand-G protein-coupled receptor (GPCR) interaction in real time without requiring purification and stabilization of the receptors, and (3) the evaluation of radiopeptide structure-related factors (length of mini-PEG linker and composition of chelator for metal labeling) affecting the in vitro and in vivo characteristics of RM26-based tracers. READ MORE