Search for dissertations about: "notch pathway"
Showing result 1 - 5 of 58 swedish dissertations containing the words notch pathway.
-
1. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer
Abstract : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. READ MORE
-
2. Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
Abstract : The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. READ MORE
-
3. Diversification of TGF-β Signaling in Homeostasis and Disease
Abstract : With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. READ MORE
-
4. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells
Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE
-
5. Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
Abstract : Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of ... READ MORE