Search for dissertations about: "novel inhibitors"
Showing result 16 - 20 of 443 swedish dissertations containing the words novel inhibitors.
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16. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion
Abstract : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. READ MORE
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17. Design and Synthesis of BACE-1 Inhibitors : Novel Compounds Targeting an Aspartic Protease Important in the Pathogenesis of Alzheimer’s Disease
Abstract : This thesis deals with the design and synthesis of protease inhibitors targeting the aspartic protease BACE-1 (β-site APP cleaving enzyme-1), an enzyme important in the pathogenesis of Alzheimer’s disease. The inhibitors are evaluated with respect to inhibition data, in a structure-activity relationship part. READ MORE
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18. Structural and functional studies of novel viral complement inhibitors
Abstract : Viruses have developed several strategies to evade the complement system, a part of the immune system. The fourth open reading frame of the human virus Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a type 1 transmembrane protein. READ MORE
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19. Development of Novel Macrocyclic Inhibitors of Protein-Protein Interactions : Applied to the Keap1-Nrf2 Complex
Abstract : .... READ MORE
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20. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors
Abstract : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. READ MORE