Search for dissertations about: "novel inhibitors"

Showing result 21 - 25 of 444 swedish dissertations containing the words novel inhibitors.

  2. 21. A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach

    Author : Sara Garbom; Hans Wolf-Watz; Dan Andersson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Yersinia; T3SS; virulence associated genes; VagH; HemK PrmC; Release factors; small molecular inhibitors; HTS; Medical microbiology; Medicinsk mikrobiologi;

    Abstract : Bacterial infections are again becoming difficult to treat because the microbes are growing increasingly resistant to the antibiotics in use today. The need for novel antimicrobial compounds is urgent and to achieve this new targets are crucial. In this thesis we present a strategy for identification of such targets via a bioinformatics approach. READ MORE

  4. 22. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

    Author : Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
    Keywords : Biokemi; Biochemistry;

    Abstract : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. READ MORE

  5. 23. Structural and Functional Studies on Human Type 2 Cystatins

    Author : Marcia Alvarez Fernandez; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; structural- functional relationships.; protein crystallography; enzyme kinetics; inhibitors; cathepsins; legumains; cystatins; cysteine peptidases;

    Abstract : Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. READ MORE

  6. 24. Novel boron compounds in lubrication

    Author : Mamoun Taher; Mark Rutland; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry of Interfaces; Gränsytors kemi;

    Abstract : Lubricants are used to control friction and reduce wear by preventing direct contact between surfaces in a relative motion. Most of the modern lubricants and lubricant additives have been designed and optimized for ferrous materials. READ MORE

  7. 25. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors

    Author : Tiago Bozzola; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sialic Acid; antibacterial agents; Medicinal Chemistry; Synthesis; uptake inhibitors;

    Abstract : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. READ MORE