Search for dissertations about: "nuclear atypia"

Found 5 swedish dissertations containing the words nuclear atypia.

  2. 1. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

    Author : David Gisselsson Nord; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

    Abstract : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. READ MORE

  4. 2. On the prognosis and treatment of early stage endometrial carcinoma : Studies with special reference to uterine papillary serous carcinoma

    Author : Per Rosenberg; Bengt Sorbe; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The prognosis and therapy in the subgroup of endometrial malignancies called Uterine Papillary Serous Carcinoma (UPSC) was investigated. This entity constitutes about 6-8 % of all endometrial carcinomas clinical stage I but, as has been shown here, accounts for one third of the cancer mortality in the early stages of endometrial carcinoma. READ MORE

  5. 3. INFLAMMATION AND PROSTATIC CARCINOGENESIS ? A MORPHOLOGICAL STUDY OF THE HUMAN PROSTATE

    Author : Wanzhong Wang; Göteborgs universitet; []
    Keywords : prostate; carcinogenesis; chronic inflammation; atrophy; morphology; immunohistochemistry;

    Abstract : ABSTRACT: Chronic inflammation has been suggested to be linked to cancers. Inflammatory infiltrates are often found in and around foci of prostatic atrophy. These foci, called proliferative inflammatory atrophy (PIA), are proposed as precursors of prostate cancer (PCa) or prostatic intraepithelial neoplasia (PIN). READ MORE

  6. 4. Ploidy, cell proliferation and apoptosis in lymphoid malignancies : methodological and clinical aspects

    Author : Magdalena Czader; Karolinska Institutet; Karolinska Institutet; []
    Keywords : image cytometry; confocal cytometry; DNA ploidy; cell proliferation; ;

    Abstract : The DNA aneuploidy and proliferative activity have been previously shown to carry a clinical significance in Iymphoid malignancies. However, the application of these parameters is complicated by methodological difficulties. READ MORE

  7. 5. A study of the transition from premalignancy to clinical prostate cancer

    Author : Alexander Valdman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Prostate cancer; immunohistochemistry; prostatic intraepithelial neoplasia; aspiration cytology;

    Abstract : Prostate cancer remains the most commonly diagnosed life-threatening malignancy and the second leading cause of death from cancer in men. However, little is known about molecular mechanisms that underline its initiation and progression. READ MORE