Search for dissertations about: "nuclear factor-kappaB"
Showing result 1 - 5 of 13 swedish dissertations containing the words nuclear factor-kappaB.
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1. Regulation of cytokine-induced nitric oxide production in insulin-producing cells
Abstract : Cytokine-induced expression of the inducible form of nitric oxide synthase (iNOS) and production of nitric oxide (NO) may contribute to pancreatic β-cell damage during the development of type 1 diabetes. iNOS catalyses the conversion of arginine into citrulline and NO, a reaction regulated by the amount of expressed iNOS enzyme and by the cellular availability of arginine. READ MORE
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2. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes
Abstract : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. READ MORE
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3. The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia
Abstract : Vascular inflammation is a hallmark of major cardiovascular diseases such as atherosclerosis, and also suggested as a critical component implicated in intimal hyperplasia. Given its central role in regulating expression of inflammatory genes, the nuclear factor kappaB (NF-kappaB) signal transduction pathway was postulated to play an important role in these pathological processes. READ MORE
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4. Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease
Abstract : Ulcerative colitis (UC) and Crohn's disease (CD) are diseases of unknown aetiology often referred to as inflammatory bowel diseases (IBD). Glucocorticosteroids (GCS) have been used since the 1950's to treat acute attacks of these diseases. READ MORE
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5. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death
Abstract : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. READ MORE