Search for dissertations about: "nuclear hormone receptor"
Showing result 1 - 5 of 80 swedish dissertations containing the words nuclear hormone receptor.
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1. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones
Abstract : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. READ MORE
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2. Functional studies on the nuclear receptor Nurr1
Abstract : The nuclear receptor (NR) superfamily comprises the largest family of ligand-activated transcription factors in eukaryotes, and it plays critical roles in many aspects of vertebrate development and physiology. The NR family is well conserved throughout evolution, and is found in organisms as diverse as nematodes, flies and mammals. READ MORE
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3. Nuclear hormone receptors studied by molecular dynamics computer simulations
Abstract : Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. READ MORE
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4. Gene regulation by nuclear hormone receptors in vivo
Abstract : The nuclear hormone receptor superfamily contains 49 different members, including those for thyroid hormone, TR? and TR?. These receptors are ligand-modulated transcription factors that activate or repress gene activity. The TR? gene encodes two main splice variants, TR?1 and TR?2. READ MORE
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5. Thyroid hormone receptor expression in cardiovascular disease and pharmacology
Abstract : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. READ MORE