Search for dissertations about: "nucleic-acid bases"

Showing result 1 - 5 of 13 swedish dissertations containing the words nucleic-acid bases.

2. 1. Nucleic acid based therapeutic approaches

   Author : Joacim Elmén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Nucleic acid therapy comprises several approaches based on nucleic acid as the active therapeutic component to treat human disease. Antisense and short interfering RNA (siRNA) are two gene-silencing techniques in this category. Based on nucleic acid sequence recognition both techniques inhibit gene expression. READ MORE

4. 2. Excitation and Ground-State Properties of Natural and Modified Nucleic Acid Bases

   Author : Anders Holmén; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ab initio; linear dichroism; DFT; transition moment; tautomerism; structure; IR; spectra; DNA bases;

   Abstract : The nucleic acid bases are the carriers of genetic information in DNA and RNA. They are also the main chromophores of nucleic acids and determine their optical properties and sensitivity to UV radiation. READ MORE

5. 3. A biophysical study of nucleic acid interactions with analogues and drugs

   Author : Ulrica Sehlstedt; Donald M Crothers; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nucleic acids; binding modes; polarised light spectroscopy; linear dichroism; NMR; triple helix; base-pair breathing dynamics; DAPI; porphyrins; quinoxaline derivatives; Biophysics; Biofysik; Biophysics; biofysik;

   Abstract : work presented in this thesis concerns studies on the physicochemical nature of interactions between nucleic acids and small ligands. The outcome of such studies can yield insights at a molecular level into the physiological mechanisms of action of biologically active nucleic-acid binding molecules. READ MORE

6. 4. Expanding the alphabet of fluorescent nucleic acid base analogues: Characterization of new members

   Author : Anke Dierckx; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; fluorescent adenine analogue; fluorescent DNA base analogue; duplex stability; Fluorescence quantum yield; circular dichroism; B-DNA;

   Abstract : Fluorescence has proven to be a powerful tool for studying structure, dynamics and interactions of biomolecules such as proteins, RNA and DNA. However, since the natural DNA/RNA nucleobases are virtually non-fluorescent, there is a need for developing fluorescent nucleic acid markers. READ MORE

7. 5. Structure and organization of genes for the predominant seminal plasma proteins semenogelin I, semenogelin II and beta-microseminoprotein

   Author : Magnus Ulvsbäck; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; transglutaminase substrate; semen coagulation; prostate; seminal vesicles; seminal plasma; rhesus monkey; human; evolution; nucleic acid sequence; cDNA; gene; semenogelin; b-microseminoprotein; Klinisk kemi; Proteins; enzymology; Proteiner; enzymologi;

   Abstract : In man, the predominant proteins in the seminal plasma include semenogelin I, semenogelin II and b-microseminoprotein (MSP). Semenogelin I and II are both synthesized in the seminal vesicles and are the backbone of the gel formed upon semen coagulation. MSP is synthesized in the prostate, but its role has not yet been defined. READ MORE