Search for dissertations about: "nucleophilic"
Showing result 1 - 5 of 114 swedish dissertations containing the word nucleophilic.
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1. Palladium-Catalyzed Nucleophilic Substitution of Alcohols : Mechanistic Studies and Synthetic Applications
Abstract : This thesis deals with the palladium-catalyzed nucleophilic substitution of π-activated alcohols in which the C–O bond of a non-manipulated hydroxyl group is cleaved. The thesis is divided in two chapters describing two different catalytic systems. READ MORE
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2. Direct Catalytic Nucleophilic Substitution of Non-Derivatized Alcohols
Abstract : This thesis focuses on the development of methods for the activation of the hydroxyl group in non-derivatized alcohols in substitution reactions. The thesis is divided into two parts, describing three different catalytic systems. READ MORE
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3. Copper-Mediated Vicarious Nucleophilic Substitution
Abstract : This thesis suggests and examines a novel approach for copper-mediated cross-couplings. We call this mechanistic approach copper-mediated vicarious nucleophilic substitution. Our hypothesis is that copper-promoted cross-couplings proceed via an intermediate s-adduct, a Meisenheimer adduct. READ MORE
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4. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling
Abstract : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. READ MORE
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5. Development of new Fluorination Methods Directed to Fluorine-18 Labelling
Abstract : This thesis deals with the development of new fluorination reactions and their application to fluorine-18 labelling. Fluorine-18 labelled compounds are employed as tracers in Positron Emission Tomography (PET), which is a powerful non-invasive imaging method in medical diagnostics. READ MORE