Search for dissertations about: "nucleoside analog"

Showing result 6 - 10 of 16 swedish dissertations containing the words nucleoside analog.

  2. 6. DNA precursor biosynthesis-allosteric regulation and medical applications

    Author : Reza Rofougaran; Anders Hofer; Thomas Borén; Staffan Eriksson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Abstract : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). READ MORE

  4. 7. Nucleoside analoge cytotoxicity-focus on enzyme regulation, metabolism, and mechanisms of resistance

    Author : Anna Fyrberg; Kourosh Lotfi; Curt Peterson; Freidoun Albertioni; Francoise Bontemps; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Farmakologi;

    Abstract : The aim of this thesis was to determine the role of nucleoside analog activating and deactivating enzymes in nucleoside analog metabolism and resistance development. Nucleoside analogs are anti-cancer drogs and are often used to treat different leukemias, attributably to presence of high levels of nucleoside analog activating enzymes in hematopoietic cells. READ MORE

  5. 8. Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs

    Author : Magnus Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; nucleoside analog; deoxycytidinekinase; deoxyguanosine kinase; thymidine kinase 1; thymidine kinase 2; deoxyribonucleosidephosphorylation; deoxyribonucleotides; anticancer therapy; antiviral therapy;

    Abstract : Deoxyribonucleoside kinases catalyze the phosphorylation of deoxyribonucleosides to deoxyribonucleoside monophosphates. There are four major deoxyribonucleoside kinasesin human cells: thymidine kinase 1 (TKl), deoxycytidine kinase (dCK), deoxyguanosinekinase (dGK), and thymidine kinase 2 (TK2). READ MORE

  6. 9. Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments

    Author : Chaoyong Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; deoxyguanosine kinase; deoxycytidine kinase; nucleoside analogs; mitochondria; phosphorylation;

    Abstract : Nucleoside analogs have been developed as anticancer and antiviral agents. The main mechanism of action of nucleoside analogs is the incorporation of the corresponding analog triphosphate into DNA where it interferes with DNA replication. READ MORE

  7. 10. Structural and functional studies of enzymes in nucleotide metabolism : a detailed investigation of two enzymes and interaction profiling of FDA-approved nucleoside analog drugs with 23 enzymes

    Author : Louise Egeblad; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Enzymes in nucleotide metabolism serve as the producers of the building blocks for DNA and RNA. From a medical perspective, nucleotide metabolism, and in particular salvage pathway enzymes, have attracted special interest, as nucleoside prodrugs given in the treatment of cancer and HIV are converted into their active metabolite forms by these enzymes. READ MORE