Search for dissertations about: "oligodendrocyte"

Showing result 11 - 15 of 59 swedish dissertations containing the word oligodendrocyte.

  2. 11. Immunogenetics and treatment of experimental autoimmune encephalomyelitis

    Author : Robert Weissert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; experimental autoimmune encephalomyelitis; major histocompatibility complex; myelin; myelin oligodendrocyte glycoprotein; T cell receptor;

    Abstract : Experimental autoimmune encephalomyelities (EAE) is a model of multiple sclerosis (MS). This experimental central nervous system (CNS) disease can be induced in rats by immunization with components of the CNS myelin sheath. READ MORE

  4. 12. Suppressive DNA vaccination in experimental autoimmune encephalomyelitis

    Author : Anna Lobell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccination; autoimmunity; experimental autoimmune encephalomyelitis; multiple sclerosis; T cell receptor; CpG motif; myelin basic protein; myelin oligodendrocyte glycoprotein;

    Abstract : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. READ MORE

  5. 13. Brain matter matters : renewal in the human brain

    Author : Maggie Yeung Wong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Many cells have a shorter life span than the organism itself and are continuously being replaced. However, for many cell types in the human body it is still largely unknown whether they turn over at all once development is complete. READ MORE

  6. 14. On molecular mechanisms of neural differentiation and forebrain development

    Author : Erik Södersten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telencephalic development is an extraordinary complex process where neural structures of highly diverse cell compositions emerge as the result of multiple developmental strategies imposing tight regulation, balance and timing of gene expression. Embryonic telencephalic neural stem cells (NSCs) can form the major cell types found in the telencephalon, and are thus an excellent model for studying transcriptional control of lineage choice mechanisms in CNS development. READ MORE

  7. 15. Stem cell-based models to study cellular alterations in Parkinson’s Disease

    Author : Margarita Chumarina; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; stem cells; IPSCs; dopaminergic neurons; oligodendrocytes; omics;

    Abstract : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. READ MORE