Search for dissertations about: "oligodendrocyte"

Showing result 16 - 20 of 59 swedish dissertations containing the word oligodendrocyte.

  2. 16. An ependymal cell quest : identification and functional role of spinal cord neural stem cells

    Author : Hanna Sabelström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Few injuries have as profound and long-lasting consequences as spinal cord injury. The primary areas of impaired function typically include sensation, mobility, bladder, bowel and sexual function. The economic, social and personal effects can also be devastating. READ MORE

  4. 17. Molecular determinants of endocannabinoid-mediated brain development

    Author : Daniela Calvigioni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous exquisitely orchestrated events taking place in the foetal brain, axonal pathfinding is of paramount importance. READ MORE

  5. 18. Immune regulation within the central nervous system and its role in demyelinating diseases

    Author : Bao-Guo Xiao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are diseases of the central nervous system (CNS) characterized by perivascular mononuclear inflammation and oligodendrocyte loss with demyelination. However, it is still not clear whether the pathology in MS and EAE is due to neuroantigen-specific CD4+ T cell-mediated autoimmune responses and/or bystander myelin damage resulting from an inflammatory response. READ MORE

  6. 19. A study of the generation of diversity in the central nervous system

    Author : Joanna Applequist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Developmental biology is concerned with understanding the mechanisms that govern the generation of a whole organism starting from one single cell. In the central nervous system (CNS) the development of different classes of neurons and glial cells involves both extrinsic signals and intrinsic cues that together govern the specification of different cell fates dependent on position within the CNS and the time of generation. READ MORE

  7. 20. Gene regulation and immune mechanisms in multiple sclerosis experimental models

    Author : Monica Sofia Calado Marta; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our strategy was to fine map and identify, in an unbiased way, genes or small regions that regulate myelin-oligodendrocyte glycoprotein-induced EAE (MOG-EAE). Such genes are important as they can then be tested for a role in MS. READ MORE