Search for dissertations about: "oligomerization"

Showing result 11 - 15 of 76 swedish dissertations containing the word oligomerization.

  2. 11. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Author : Caroline Sandén; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Abstract : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. READ MORE

  4. 12. The complex world of proteins: Structure, function, and oligomerization of frataxin

    Author : Christopher Söderberg; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Frataxin; Friedreich s ataxia; self-assembly; protein-protein interaction; iron homeostasis; SAXS; cross-linking;

    Abstract : Patients suffering from the deadly progressive neurodegenerative disease Friedreich's ataxia have reduced levels of expression of the protein frataxin. Yeast frataxin has been extensively studied in vitro, and has been shown to deliver iron to heme and iron-sulfur cluster biosynthesis, as well as to oligomerize in the presence of iron. READ MORE

  5. 13. Assembly and entry mechanisms of Semliki Forest virus

    Author : Bernd Uwe Barth; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest virus; virus assembly; protein oligomerization; virus budding;

    Abstract : The genomes of enveloped viruses are packaged into a core or nucleocapsid (NC) which is surrounded by a lipid membrane with spike proteins. These viruses mature by budding at a membrane of the host cell, usually the plasma membrane (PM), and penetrate into new ones by a virus-host membrane fusion event. READ MORE

  6. 14. Innate immunity atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide

    Author : Kristina Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atherosclerosis; innate immunity; inflammation; Toll-like receptor; nucleotide oligomerization domain protein; antimicrobial peptide;

    Abstract : Atherosclerosis, a disease characterized by fibroinflammatory lipid lesions in the arterial wall, is the leading cause of mortality in the Western world. For decades research has been aimed at dissecting the pathogenesis of this multifactorial disease. READ MORE

  7. 15. Topology and membrane rearrangements of the hepatitis C virus protein NS4B

    Author : Marika Lundin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C virus; NS4B; NS5A; topology; posttranslational translocation membrane rearrangements; endoplasmic reticulum; polyprotein; membrane protein; membrane associated foci; oligomerization; viral replication; replicon; replication complex; mutations; immunoprecipitation;

    Abstract : Hepatitis C virus (HCV) is a major cause of chronic liver disease and viral hepatitis around the world. Approximately 180 million people or 3% of the world's population are infected with the virus. READ MORE