Search for dissertations about: "omeprazole"

Showing result 21 - 25 of 37 swedish dissertations containing the word omeprazole.

  2. 21. CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions

    Author : Staffan Rosenborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20% of all drugs. All CYP2C enzymes are polymorphic, i.e. READ MORE

  4. 22. Pharmaceutical and mutational interference with virulence of Salmonella enterica serovar typhimurium

    Author : Aurel Negrea; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Within the species Salmonella enterica are a diverse range of bacteria that can cause illness in humans and many animals. Salmonellae are extremely versatile and can adapt to a variety of environments and hosts. Typhoid and paratyphoid fever, caused by human-restricted S. enterica serovars Typhi and Paratyphi are common in the developing world. READ MORE

  5. 23. Pharmacokinetics, drug metabolism and clinical effects of the antimalarial artemisinin : Time-dependencies and modeling aspects

    Author : Ulrika Sigrid Helena Svensson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; Biofarmaci;

    Abstract : The mechanism behind artemisinin time-dependent bioavailability was investigated using a rat in-situ single-pass jejunal perfusion technique. The consequence for drug combination therapy was studied in healthy volunteers and in patients with Plasmodium falciparum. READ MORE

  6. 24. Enantioseparation of drugs and related compounds using chiral mobile phase additives

    Author : Ngoc Hang Huynh; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Neutral and anionic chiral mobile phase additives have been employed to separate enantiomers of drugs and related compounds using aqueous buffer solution and hydro-organic solvent mixtures as mobile phases.Ester derivatives of tartaric acid, e. g. READ MORE

  7. 25. Expression of Genes Encoding for Drug Metabolism in the Small Intestine

    Author : Monica Lindell; Hans Lennernäs; Matti Lang; Olavi Pelkonen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; CYPs; UGTs; interindividual variation; small intestine; human; rat; artemisinin; CAR-receptor regulation; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : This investigation focused on the mRNA expression of drug metabolising Cytochromes P-450 (CYP) and UDP-glucuronosyltransferases (UGT) and the transport protein P-glycoprotein (Pgp) in the small intestine of humans and rats.The mRNA expression of the investigated genes in the human small intestine (duodenum) varies between individuals giving each one of us personal profile. READ MORE