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Showing result 1 - 5 of 85 swedish dissertations matching the above criteria.

2. 1. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity

   Author : Kristina Juneblad; Gerd-Marie Alenius; Solbritt Rantapää-Dahlqvist; Lars-Erik Kristenssen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psoriatic Arthritis; genetics; inflammasomes; polymorphisms; biomarkers; disease expression; disease activity; cardiovascular diseases; mortality; epidemiology;

   Abstract : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. READ MORE

4. 2. Rheumatoid Arthritis in a 10-Year Perspective, Outcome for Patients Followed from Early Disease

   Author : Elisabet Lindqvist; Reumatologi och molekylär skelettbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; rheumatology locomotion; Skelett; COMP; Skeleton; muscle system; Anti-IL-1alpha; Anti-CCP; Rheumatoid factor isotypes; Mortality; Radiographic progression; Joint damage; Disease activity; HAQ; SOFI; Disability; Prognosis; Rheumatoid arthritis; Outcome;

   Abstract : Rheumatoid arthritis (RA) is characterized by persistent inflammation, progressive joint damage and disability. This thesis describes the outcome after 10 years in a cohort of 183 RA patients (116 women, 67 men) recruited 1985-89. The mean age was 51 years and symptom duration 11 months at inclusion. READ MORE

5. 3. Measure for measure. Outcome assessment of arthritis treatment in clinical practice

   Author : Anders Gülfe; Reumatologi och molekylär skelettbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF blockade; rheumatoid arthritis; utility; treatment continuation; agreement; health related quality of life; Outcome; response; psoriatic arthritis; spondyloarthritis; disease activity; observational study;

   Abstract : Objective: To investigate (i) the performance and agreement between various activity indices and response criteria in TNF-blockade of RA; (ii) the predictive ability of different response criteria and disease activity states regarding continuation of anti-TNF treatment of RA; (iii) Euro-QoL-5-dimensions utility development during TNF blockade of RA, PsA and SpA. Also, (iv) to develop a simple, utility-based outcome measure, the number needed to treat per quality adjusted life year gained (NNQ) and apply it in RA, PsA and SpA patients on anti-TNF treatment. READ MORE

6. 4. Proteases in Staphylococcal Arthritis

   Author : Ann-Marie Calander; Göteborgs universitet; []
   Keywords : Staphylococcus aureus; Septic arthritis; Proteases; Matrix metalloproteinases;

   Abstract : Proteases in Staphylococcal Arthritis Ann-Marie Calander Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Göteborg University, Guldhedsgatan 10A, 413 46 Göteborg, Sweden Staphylococcus aureus (S. aureus) is a ubiquitous bacterium. READ MORE

7. 5. T cells and chemokines in rheumatoid arthritis

   Author : Jonathan Aldridge; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; CD4 T cells; chemokines; disease activity; biomarker; CTLA-4Ig;

   Abstract : In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early rheumatoid arthritis (eRA). We also compared the effect of different biological treatments on both T cell subset proportions and chemokine levels. READ MORE